Abstract: Many studies have now demonstrated that lesions to, or stimulation of, the vestibular system, can alter neuronal activity in the hippocampus and striatum.Vestibular modulation of these areas of the brain is known to affect the development of both spatial memory and motor plans for action. Nonetheless, we still have a limited understanding of how vestibular input modulates hippocampal and striatial activity, and through what routes of synaptic transmission. This presentation will describe new studies in which we and researchers at the University of Caen have investigated the effects of selective electrical stimulation of different parts of the rat vestibular labyrinth on electrophysiological activity in different subregions of the hipppocampus. Other related studies have investigated the identity of the hippocampal neurons affected by vestibular stimulation. In separate studies we have explored the effects of electrical stimulation of the rat vestibular labyrinth on single neuron activity and c-Fos expression in the striatum. In related studies we have investigated the effects of similar vestibular stimulation on neurotransmitter release using in vivo microdialysis. We hope that these studies will contribute to a better understanding of how vestibular information is used by the hippocampus and striatum, both separately and together.
Date et heure : le 06/02/2018 à 14h00
Lieu : PS1-080 (PFRS)